Blueberries should be picked when they are fully ripe, which means they have turned a solid dark purple-blue color with no hints of pink or red. They should detach easily from the bush with a gentle roll between your fingers, indicating they are ready to harvest. The best time to pick is usually from late June through August, varying by climate and growing zone. It's important to wait 5-7 days after they first turn blue for optimal sweetness and flavor development, as blueberries do not continue to ripen after being picked. Picking early in the morning when the berries are cool and firm is ideal for the best quality. Avoid picking berries that are still light blue or have any green or pink tint, as they will be more tart and less sweet.