The main cast of "Why Women Kill" Season 2 includes:
- Allison Tolman as Alma Fillcot, a housewife in 1949 who is desperate to join a local exclusive garden club.
- Lana Parrilla as Rita Castillo, the president of the garden club and a gold-digging wife.
- B.K. Cannon as Dee Fillcot, Alma's daughter.
- Jordane Christie as Vern Loomis, a private investigator.
- Matthew Daddario as Scooter, a struggling actor and Rita's paramour.
- Verónica Falcón as Catherine Castillo, Rita's stepdaughter.
- Nick Frost as Bertram Fillcot, Alma's husband and a veterinarian.
- Rachel Bay Jones as Maisie.
- Daniel Zacapa as Carlo Castillo, Rita's elderly husband.
- Eileen Galindo as Isabel, Rita's maid and accomplice.
- Rondi Reed as Mrs. Carol Yost, the judgmental neighbor.
- Virginia Williams, Jessica Phillips, Kerry O'Malley, and Cynthia Quiles as other garden club members.
- Jack Davenport as The Narrator.
- Warren Kole as Detective Rohbin.
- Ryan McPartlin as Tom Madison.
- Andrew Leeds as Dr. Gibson.
This season is set in 1949 Los Angeles and focuses on the story of Alma Fillcot and Rita Castillo, exploring themes like beauty, societal facades, and the effects of neglect leading to murder.