Nipple pain can be caused by a variety of factors including breastfeeding challenges, hormonal changes, infections, friction or chafing from clothing or physical activity, allergies or skin sensitivities, eczema or psoriasis, certain medications, pregnancy-related breast growth, trauma or injury, and sometimes breast cysts or lumps. In women, breastfeeding is a common cause due to poor latch or prolonged feeding, and hormonal fluctuations during menstrual cycles, pregnancy, or breastfeeding can increase sensitivity. Friction during exercise or from tight clothing can also cause irritation known as "jogger’s nipple." Infections such as yeast infections or bacterial infections can cause soreness, as can allergic reactions to soaps, lotions, or fabrics. Rarely, nipple pain may indicate conditions such as Paget’s disease, a form of breast cancer, which requires medical evaluation. For men, causes can include hormonal changes, friction, skin conditions, infections, or side effects of medications. If nipple pain persists, worsens, or is accompanied by other concerning signs like redness, swelling, discharge, fever, or lumps, it is important to seek medical advice to rule out serious conditions and get appropriate treatment.