Tick bites itch primarily because of chemicals in the tick's saliva that cause an immune response in the skin. When a tick bites, it injects saliva that contains substances like anesthetics to numb the area and anticoagulants to keep blood flowing, which generally prevent pain and itching while the tick feeds. However, for many people, the immune system recognizes proteins in the saliva as foreign and responds with inflammation, redness, and itchiness at the bite site. This reaction typically causes the itching sensation associated with tick bites. Additionally, repeated tick bites can increase the likelihood of itching as the immune system becomes more sensitized to these proteins. If the tick’s head remains embedded after removal, it can also cause itchiness and inflammation. Itching shortly after the bite is usually not a sign of Lyme disease but rather a reaction to the bite itself or, in some cases, an allergic reaction to tick saliva. In summary, tick bites itch because the body's immune system reacts to certain chemicals in tick saliva, causing localized inflammation and itching. This itchiness is a normal inflammatory response and not necessarily indicative of disease like Lyme disease, which has different symptoms developing over days or weeks after the bite.