Lawrence Kutner's suicide on the TV show House MD was intentionally left unexplained in the storyline. The character's death was a shock to fans, and no clear reason was given within the show itself. The real-world reason for Kutner's death by suicide was that the actor Kal Penn chose to leave the show to work in the White House. The show's creator wanted to reflect the theme that some things, including the reasons behind suicide, are complex and unsolvable—even for the character of Dr. House, who is known for solving medical mysteries. The show deliberately did not provide a diagnosis or reason for Kutner's suicide, underscoring that sometimes people we think we know well may still have hidden struggles. Off-screen, Penn's departure led to the decision to have Kutner die by suicide, but in the show, the reason remains unknown and is a poignant part of the story's exploration of human complexity and mental health.