Justin Chambers left Grey's Anatomy primarily because he wanted to diversify his acting roles and career choices after being with the show for 15 years. He expressed that it was time for a new chapter as he approached 50, with a supportive family and a desire to pursue different opportunities outside of Grey's Anatomy. His departure was announced in early 2020, after his last on- screen appearance in season 16, episode 8. The character Alex Karev was written out by having him reunite with his former flame Izzie Stevens and their children, which some fans found controversial as it seemed to undo some of his character development. Chambers thanked the cast, crew, and creator Shonda Rhimes upon his exit, and he decided to leave on his own terms rather than being written off or killed. There are also some speculations and rumors about health and behind-the-scenes issues, but the official reason given by Chambers focuses on career diversification and personal growth.