Unintentional weight loss—the kind that happens without trying or changing diet or exercise—can be caused by a variety of factors including stress, mental health conditions such as depression or anxiety, digestive disorders like celiac disease or inflammatory bowel disease, hormone issues such as an overactive thyroid, or serious illnesses including cancer. Sometimes medications or side effects can also lead to weight loss. Because weight loss without trying might indicate a health problem, it is important to consult a healthcare provider to identify the underlying cause and get appropriate treatment, especially if the weight loss is significant or accompanied by other symptoms.