The nonpolar part of the plasma membrane is the interior region formed by the fatty acid tails of the phospholipids. These fatty acid tails are hydrophobic (water-fearing) and nonpolar, which means they do not interact with water or polar molecules. This interior region lies between the two layers of the phospholipid bilayer, while the polar, hydrophilic (water-loving) heads face the aqueous environments inside and outside the cell. Thus, the plasma membrane is composed of a phospholipid bilayer with polar heads on the outside and inside surfaces and a nonpolar, hydrophobic core formed by the fatty acid tails in the middle. This nonpolar core acts as a barrier to polar molecules, allowing the membrane to be selectively permeable.
