The series "House of Guinness" was filmed primarily in Northern England, despite being set in 19th-century Dublin and New York. Key filming locations include:
- Liverpool: Stanley Dock served as the Guinness brewery, Croxteth Hall was used for the exterior of the Guinness family home (Iveagh House), and Sefton Park Palm House was used for botanical garden scenes. Liverpool also featured locations like Collingwood Docks, Tobacco Warehouse, Stanley Docks, and William Brown Street.
- Greater Manchester: The Northern Quarter of Manchester was used to represent New York City, while places like St Philips Church in Salford, Heaton Hall, Ancoats, and Little Underbank in Stockport (transformed into The Oak pub) were used for various scenes.
- Cheshire: Filming began here, including the National Waterways Museum in Ellesmere Port, which doubled as 19th-century docks, and Tatton Park, a mansion used in the series.
- Yorkshire: Broughton Hall estate was used to film a country retreat in the series.
- Wales: Penrhyn Castle in North Wales represented the Ashford Estate, and Gwynedd in Snowdonia was used to film rural scenes meant to represent parts of Ireland.
The production chose these locations because they have architecture closer to 1860s Dublin than modern Dublin itself, allowing for authentic period settings without heavy digital effects.