Brock Purdy is expected to return to practice with limited participation as of Wednesday, September 17, 2025. His toe injury has improved enough for him to engage in limited practice, and San Francisco 49ers head coach Kyle Shanahan has said Purdy "has a chance" to play in Week 3's home game against the Arizona Cardinals. However, the final decision will depend on how Purdy feels throughout the week and how he performs in practice. There is still the possibility he might only serve as an emergency quarterback if not fully ready. Earlier estimates had Purdy potentially returning around Week 4 or Week 5, but his recovery is going faster than initially expected, and he might miss only one game so far. If he does not play in Week 3, he is likely to return by Week 4 against the Jacksonville Jaguars or Week 5 in the short-week matchup against the Los Angeles Rams.
