The best flea treatment for cats in 2025 includes several highly effective options, both prescription and over-the-counter (OTC). The top prescription topical treatment recommended is Revolution Plus, which not only eliminates fleas and ticks but also protects against heartworms, roundworms, hookworms, ear mites, and tapeworms. It is easy to apply monthly on the skin at the base of the neck and is highly effective with a quick absorption liquid formula. For OTC options, Frontline Plus for Cats is an excellent choice. It kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice with one easy monthly application. Fleas die on contact, and it does not require a vet prescription. Fast-acting oral treatments like Comfortis Chewable Tablets start killing fleas within 30 minutes and provide month-long protection, ideal for cats that cannot tolerate topical treatments. Seresto Flea and Tick Collar is another option but generally less effective than topical and oral treatments. Overall, the best treatment depends on the cat's age, health conditions, and lifestyle. Consulting a veterinarian is important to choose the safest and most effective product, especially avoiding products made for dogs, which are toxic to cats.