Motor neurone disease (MND) is a group of progressive neurological disorders that affect the motor nerves (motor neurons), which are nerve cells in the brain and spinal cord that control muscle activity such as movement, swallowing, talking, and breathing. In MND, these motor neurons become damaged and eventually die, which disrupts the nerve signals to muscles, causing muscle weakness, wasting (atrophy), stiffness, and twitching. Over time, this leads to paralysis and difficulty with essential functions like breathing and swallowing. MND includes several specific diseases such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), progressive muscular atrophy, progressive bulbar palsy, primary lateral sclerosis, and Kennedy's disease. Symptoms usually begin with mild muscle weakness in parts of the body (such as legs or hands) and progressively worsen. Other symptoms may include muscle cramps, twitching, slurred speech, difficulty swallowing, breathing problems, fatigue, and sometimes mild changes in cognition or behavior. The disease does not affect the senses like sight, hearing, smell, taste, or touch. MND mainly affects people over 50 years old but can occur earlier. The cause is usually unknown, but some cases have genetic links. Unfortunately, there is no cure. Treatment focuses on managing symptoms and improving quality of life. The average survival time is often 2-5 years after diagnosis, though this varies. In summary, MND is a life-limiting neurological condition characterized by progressive muscle weakness and loss of movement control due to the degeneration of motor neurons responsible for muscle activity. It significantly affects mobility and vital functions such as breathing and swallowing. This explanation is based on comprehensive information from health organizations and neurological research sources.