Leucovorin is primarily used to reduce the toxic effects of high-dose methotrexate, a chemotherapy drug, by protecting healthy cells from its harmful effects. It is also used along with chemotherapy drugs like 5-fluorouracil to improve their effectiveness, particularly in colorectal cancer treatment. Additionally, leucovorin is employed to treat certain types of anemia caused by folic acid deficiency and to counteract the toxic effects of medications that block folic acid's action, such as pyrimethamine. It can be given orally or by injection and is sometimes used in other conditions as determined by a healthcare provider.
