EDDP is a metabolite of methadone, a medication used to treat opioid addiction. It is difficult to detect using an immunoassay, which is why it is often measured as part of a urine drug screen. EDDP is a primary metabolite of methadone, and its presence in a urine sample is a more reliable indication that the patient has been taking methadone and helps to prevent pill dropping. A positive result for both methadone and EDDP confirms methadone ingestion. The EDDP urine test is a qualitative assay that delivers a "NEGATIVE" or "POSITIVE" result.