DMSO gel is a topical formulation of dimethyl sulfoxide (DMSO), a colorless chemical solvent derived as a by-product from wood pulp in the paper production process. DMSO gel is primarily used to relieve pain and inflammation, and may help with healing wounds, burns, and muscle or skeletal injuries. Medically, DMSO is FDA-approved to treat interstitial cystitis (a painful bladder condition) under the brand name Rimso-50. Its gel or cream form is commonly available without a prescription and is applied to the skin to reduce pain from conditions like osteoarthritis and rheumatoid arthritis, though scientific evidence of effectiveness varies. Because DMSO can penetrate the skin easily, it is sometimes used to enhance the absorption of other medications. Typical DMSO gels can have concentrations ranging from 10% to 90%, with around 25% being typical for osteoarthritis treatment and applied multiple times a day. While DMSO has anti-inflammatory and antioxidant properties and may help in pain management, it is not proven or approved for many of the other uses it is sometimes promoted for, such as cancer treatment or extensive wound healing. It should be used cautiously, as it can carry substances through the skin into the body. In summary, DMSO gel is a topical preparation used for pain relief and inflammation, with some approved medical uses and several off-label applications, mostly applied directly to the skin.