Contrave is a prescription weight-loss medicine that contains a combination of two active components, naltrexone and bupropion. Naltrexone is used to treat alcohol and opioid dependence, while bupropion is an antidepressant medicine that can also decrease appetite. Contrave is intended to be used along with a reduced-calorie diet and increased physical activity. It is FDA-approved to help adults lose weight when combined with a balanced diet and exercise. Contrave is not approved to treat depression or other psychiatric conditions, or to help you quit smoking. It is important to note that Contrave can cause serious side effects, including suicidal thoughts or actions, and should only be used under the supervision of a healthcare provider.