A Luer lock syringe is a type of syringe that has a locking mechanism to create a secure attachment between the needle and the syringe. The needle is inserted into the syringe and twisted to form a locked connection, which ensures that no liquids can leak and prevents accidental removal of the needle. Luer lock syringes require the hypodermic needle to be screwed on, rotating the needle clockwise can achieve a very tight fit bond between the needle and the syringe. The advantage of a Luer Lock design is that it creates a more secure attachment, allowing for the connection to sustain higher pressures with a reduced risk of leaks or pop-off.
In contrast, a Luer slip syringe uses a friction-fit connection method. The needles hub is pushed onto the syringe tip in a twisting motion for a tight fit. A Luer slip design allows for a needle to be conveniently attached more quickly, and the extent of the twisting motion used to fasten a needle to a Luer Lock syringe may fatigue a hand quicker than the motion that is required for a Luer Slip syringe, making the Luer Slip connection beneficial if the users application requires a lot of this repetitive motion. The potential lower manufacturing costs for Luer Slip syringes may also make them a more cost-effective option.