Ben Shelton was forced to retire from his third-round match at the 2025 US Open due to a left shoulder injury. The injury occurred during the fourth set of his match against France's Adrian Mannarino. Shelton initially played well, winning the first and third sets, but began experiencing significant shoulder pain early in the fourth set. Despite receiving treatment and attempting to continue, the pain worsened, leading to his retirement from the match after more than three hours of intense play. This was the first time in his 178-match career that he had to retire from a contest. Shelton was emotional about the decision but prioritized his long-term health, as he did not want to risk his career or future major title aspirations. His father and coach advised him to stop. Shelton expressed gratitude for his recent successful summer and remained positive despite the setback.