The Season 22 premiere of Grey's Anatomy, which aired on October 9, 2025, picks up right after a catastrophic explosion at Grey Sloan Memorial Hospital. The explosion was one of the most significant hospital disasters in the show's history, leaving many characters' fates uncertain. The key events are:
- Monica Beltran (played by Natalie Morales) was the only fatality from the explosion. She was trapped underneath hospital equipment, tried to assist during surgery despite her injuries, but ultimately died on the operating room floor.
- Atticus "Link" Lincoln (Chris Carmack) was injured and trapped under rubble but survived after a challenging rescue and surgery.
- Meredith Grey, the main character played by Ellen Pompeo, survived the explosion and took matters into her own hands to reopen the clinic.
- There was emotional trauma and hospital chaos as doctors struggled to save patients and themselves.
- The season premiere also explores the aftermath of the explosion on characters like Amelia Shepherd, Jules Millin, and others.
- Showrunner Meg Marinis discussed the difficult decision to kill off Monica, highlighting her character's dedicated nature toward patients.
- This season includes both dramatic character developments and milestone episodes, such as the 450th episode of the series.
Overall, Grey's Anatomy Season 22 began with high tension and emotional stakes following the hospital explosion and set the stage for further developments around the survivors and their medical missions.