George O'Malley dies in the first episode of season 6 of Grey's Anatomy , titled "Good Mourning"
. This episode originally aired on September 24, 2009, and marks the official on-screen death of the character following injuries he sustained at the end of season 5
. The dramatic accident that leads to his death actually occurs in the season 5 finale, "Now or Never," where George is hit by a bus while saving a stranger, but his death is confirmed and explored in depth in the season 6 premiere