Wellbutrin is the brand name for bupropion, an atypical antidepressant medication primarily used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD) - a type of depression related to seasonal changes
. It works by increasing the levels of the neurotransmitters norepinephrine and dopamine in the brain, which are chemicals that help regulate mood and emotions
. Unlike many other antidepressants, Wellbutrin does not typically cause sexual dysfunction or weight gain and may be more effective in improving symptoms like fatigue and hypersomnia (excessive sleepiness)
. It is also distinct from selective serotonin reuptake inhibitors (SSRIs) because it does not affect serotonin but instead inhibits the reuptake of norepinephrine and dopamine, classifying it as a norepinephrine and dopamine reuptake inhibitor (NDRI)
. Additionally, bupropion is sometimes used off-label or as an add-on treatment when first-line antidepressants are not fully effective
. Another formulation of bupropion, Zyban, is used to help people quit smoking, though Wellbutrin itself is not indicated specifically for smoking cessation
. In summary, Wellbutrin is used to:
- Treat major depressive disorder (MDD)
- Treat seasonal affective disorder (SAD)
- Support smoking cessation (under the brand Zyban, a form of bupropion)
It helps by increasing norepinephrine and dopamine activity in the brain, which improves mood and energy levels
