AFL can stand for several different organizations or concepts, depending on the context. The most common meanings are:
- Australian Football League : The national governing body for Australian Rules football, commonly known as "Footy" or "Aussie Rules," and the premier professional competition for the sport in Australia
- American Football League : A professional American football league that operated in the United States from 1960 to 1969 before merging with the National Football League (NFL)
- American Federation of Labor : A historic federation of labor unions in the United States, which merged with the Congress of Industrial Organizations in 1955 to form the AFL-CIO
Other less common meanings include the Arena Football League, Alberta Federation of Labour, and various other organizations and terms