The main cast of "Orange Is the New Black" includes:
- Taylor Schilling as Piper Chapman
- Laura Prepon as Alex Vause
- Michael Harney as Sam Healy
- Kate Mulgrew as Galina "Red" Reznikov
- Danielle Brooks as Tasha "Taystee" Jefferson
- Uzo Aduba as Suzanne "Crazy Eyes" Warren
- Natasha Lyonne as Nicky Nichols
- Taryn Manning as Tiffany "Pennsatucky" Doggett
- Selenis Leyva as Gloria Mendoza
- Adrienne C. Moore as Cindy "Black Cindy" Hayes
- Dascha Polanco as Dayanara "Daya" Diaz
- Nick Sandow as Joe Caputo
- Yael Stone as Lorna Morello
- Samira Wiley as Poussey Washington
- Jackie Cruz as Marisol "Flaca" Gonzales
- Lea DeLaria as Carrie "Big Boo" Black
- Elizabeth Rodriguez as Aleida Diaz
- Jessica Pimentel as Maria Ruiz
The show also notably cast Laverne Cox as Sophia Burset, a transgender character, which was highlighted as a groundbreaking choice for the series. This is a list of the key characters and actors who appeared prominently through the show's seven seasons.