The main cast of the Lethal Weapon TV show (2016–2019) includes:
- Damon Wayans as Roger Murtaugh, a seasoned detective
- Clayne Crawford as Martin Riggs, a reckless detective (Seasons 1 and 2)
- Keesha Sharp as Trish Murtaugh, Roger's wife (replacing Golden Brooks)
- Kevin Rahm as Captain Brooks Avery, the precinct captain
- Michelle Mitchenor as Detective Sonya Bailey
- Jordana Brewster as Dr. Maureen "Mo" Cahill (Season 3)
- Seann William Scott as Wesley Cole (Season 3), who replaces Riggs as Murtaugh's partner
Additional recurring characters include Leo Getz (Thomas Lennon), Gina Santos (Michelle Hurd), and others introduced throughout the series
. This ensemble portrays the dynamic between mismatched detective partners and their families in a modern take on the classic Lethal Weapon franchise
