Most aerobic respiration takes place in the mitochondria of a cell. Specifically:
- Glycolysis, the initial stage, occurs in the cytoplasm.
- The link reaction and the Krebs cycle take place in the matrix of the mitochondria.
- Oxidative phosphorylation happens at the inner membrane of the mitochondria.
Hence, the majority of the aerobic respiration process, including crucial energy-producing steps like the Krebs cycle and oxidative phosphorylation, occurs in the mitochondria, with only glycolysis occurring in the cytoplasm.