It is not possible to completely get rid of a cold sore within 24 hours, but starting treatment immediately at the first sign (such as tingling or itching) can significantly reduce duration and severity. The fastest and most effective approach involves antiviral medications like acyclovir, valacyclovir, or famciclovir, which work best if started within the first 24 to 48 hours. Over- the-counter antiviral creams like docosanol (Abreva) can also help speed healing if applied early. Additional fast relief methods include applying a cold compress or ice wrapped in a cloth several times a day to numb pain and reduce swelling, using pain relievers like acetaminophen or ibuprofen, and keeping lips moisturized with UV-protective lip balm to prevent cracking. Natural remedies such as lemon balm, tea tree oil, peppermint oil, and manuka honey may soothe symptoms and promote healing, though evidence is less conclusive. In summary, quick initiation of antiviral treatment combined with cold compresses and supportive care can help shorten a cold sore outbreak as much as possible, but complete disappearance within 24 hours is unrealistic. The typical healing process usually takes several days to a couple of weeks despite these measures.