The main cast of How to Get Away with Murder includes:
- Viola Davis as Annalise Keating, a defense attorney and law professor
- Alfred Enoch as Wes Gibbins, one of Annalise's students
- Jack Falahee as Connor Walsh, one of Annalise's students
- Aja Naomi King as Michaela Pratt, one of Annalise's students
- Matt McGorry as Asher Millstone, one of Annalise's students
- Karla Souza as Laurel Castillo, one of Annalise's students
- Billy Brown as Nate Lahey, a detective and Annalise's lover
- Charlie Weber and Liza Weil as Annalise's employees
- Conrad Ricamora, promoted to main cast starting season 3
These actors form the core ensemble around which the series revolves, portraying a group of law students and their professor entangled in complex murder cases