There is currently no definitive cure or medication that completely eliminates hepatitis B virus (HBV) or guarantees conversion from hepatitis B surface antigen (HBsAg) positive to negative status. However, antiviral treatments such as entecavir, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF) are effective in suppressing the virus, reducing liver damage, and improving liver function. In rare cases, these treatments may lead to HBsAg becoming negative, which indicates clearance of the virus
. Key points on converting hepatitis B positive to negative:
- Antiviral therapy : First-line antivirals (entecavir, tenofovir) can suppress viral replication and improve liver health. Pegylated interferon may also be used in some cases
- Spontaneous clearance : Some people with acute hepatitis B may clear the infection naturally over time, leading to HBsAg negativity without treatment
- Lifestyle factors : Maintaining a healthy lifestyle-avoiding alcohol, smoking, obesity, and managing stress-can improve chances of clearing HBsAg and developing protective antibodies
- Monitoring and follow-up : Even after HBsAg loss, regular monitoring is essential to check for viral reactivation, especially if immunosuppressive treatments are needed
- Natural and supportive measures : While some natural approaches (healthy diet, avoiding liver toxins) support liver health, they do not replace antiviral therapy
In summary, while complete conversion from hepatitis B positive to negative is uncommon and not guaranteed, antiviral treatments combined with healthy lifestyle choices can suppress the virus effectively and in some cases lead to HBsAg clearance. Regular medical follow-up is crucial to manage the infection and liver health
