For most vaginal yeast infections, fluconazole is typically taken as a single 150 mg oral dose. If symptoms do not improve within about three days, a healthcare provider may recommend a second dose taken 72 hours after the first. In cases of recurrent yeast infections, the Centers for Disease Control and Prevention (CDC) recommends a maintenance plan involving weekly doses (100 mg, 150 mg, or 200 mg) of fluconazole for six months. It is important not to take fluconazole more frequently than prescribed, as overuse can lead to side effects such as headache, nausea, stomach pain, diarrhea, dizziness, or skin rash and may also contribute to antifungal resistance. For recurrent vulvovaginal candidiasis (three or more infections in a year), doctors may prescribe daily doses for a time followed by weekly maintenance doses for six months. In summary:
- Single dose of 150 mg is standard for a typical yeast infection.
- If symptoms persist, a second dose can be taken 72 hours later.
- For recurrent infections, weekly dosing for up to six months may be recommended under medical supervision.
- Always follow healthcare provider instructions to reduce risk of resistance and side effects.