Four U.S. presidents have been assassinated while in office:
- Abraham Lincoln (16th president) in 1865
- James A. Garfield (20th president) in 1881
- William McKinley (25th president) in 1901
- John F. Kennedy (35th president) in 1963
These four presidents were fatally shot by assassins during their terms, marking the only successful presidential assassinations in U.S. history.