Deion Sanders has three sons who have played football:
- Deion Sanders Jr., the eldest son, played college football as a wide receiver at Southern Methodist University (SMU) but did not play professionally
- Shedeur Sanders, the youngest son, played quarterback in college at Jackson State and Colorado and was drafted by the Cleveland Browns in the fifth round of the 2025 NFL Draft
- Shilo Sanders, another son, played safety in college at South Carolina, Jackson State, and Colorado, and signed with the Tampa Bay Buccaneers as an undrafted free agent in 2025
Thus, three of Deion Sanders' sons have played football, with two currently in the NFL as of 2025
