Hand, foot, and mouth disease (HFMD) is most contagious during the first week of illness, particularly in the first few days when symptoms like fever and rash appear
. However, the virus can still be spread to others for days or even weeks after symptoms have resolved, especially because the virus can remain in the stool for several weeks after the blisters have healed
. The typical isolation period to prevent spreading HFMD is about 7 to 10 days, and people are generally advised to stay home until they have been fever-free for at least 24 hours and all blisters have healed
. Despite recovery, the virus can continue to be shed in respiratory secretions and feces for weeks, which means transmission to others can still occur even if no symptoms are present
. In summary:
- Most contagious: First week of illness, especially first few days
- Contagious period: Can last several days to weeks after symptoms resolve due to viral shedding in stool and respiratory secretions
- Recommended isolation: 7–10 days, until fever-free for 24 hours and blisters have healed
This prolonged contagious period is why good hygiene practices, such as frequent handwashing and disinfecting surfaces, are important to prevent spread even after symptoms improve
