Nexium (esomeprazole) typically starts to work within 1 to 4 days, but it may take up to 2 to 4 weeks for the full effect to be felt. Some people experience relief within hours or a day, while for others, it takes a few days of regular intake before symptoms improve significantly. Nexium provides up to 24 hours of relief from frequent heartburn with one pill per day. It is not intended for immediate symptom relief like antacids, which neutralize acid quickly. If symptoms persist or worsen after 14 days of treatment, a healthcare provider should be consulted. Nexium works by reducing stomach acid production through proton pump inhibition, which takes a short time to affect acid levels but longer for the parietal cells in the stomach to regenerate after being inhibited. In summary:
- Initial relief: within 1 to 4 days
- Full effect: may take up to 2 to 4 weeks
- Duration of relief per dose: up to 24 hours
- Not for immediate symptom relief but effective for frequent heartburn management
This timeline can vary by individual and depends on consistent daily use and other factors like diet and overall health.