Amoxicillin begins to work in the body quite quickly, typically within 1 to 2 hours after oral administration, as it reaches peak blood levels in this timeframe
. However, while the drug starts killing bacteria soon after absorption, it usually takes about 24 to 72 hours (1 to 3 days) for most people to notice an improvement in symptoms of infection
. The onset of action is rapid because amoxicillin inhibits bacterial cell wall synthesis, leading to bacterial death
. Despite this fast action, symptoms do not resolve immediately because it takes time to clear the infection from the body
. Extended-release forms of amoxicillin may take a bit longer-around 3 hours- to reach full effectiveness
. Patients are advised to complete the full prescribed course of amoxicillin even if they start feeling better within a few days, to ensure the infection is fully eradicated and to prevent antibiotic resistance
. In summary:
- Amoxicillin starts working within 1 to 2 hours after taking a dose.
- Symptom improvement generally occurs within 24 to 72 hours.
- Extended-release forms may take slightly longer to act.
- Full course completion is essential despite early symptom relief.
This timeline can vary depending on the infection type, severity, and individual patient factors
