Amoxicillin typically stays in your system for about 8 to 12 hours after your most recent dose. It has a relatively short elimination half-life of approximately 1 hour (61.3 minutes), meaning the concentration of the drug in your body reduces by half every hour
. About 60% of the absorbed amoxicillin is excreted through the kidneys and urine within 6 to 8 hours, and after 12 hours, it is generally undetectable in the bloodstream for most people
. However, the exact duration can vary depending on factors such as the dose taken, body weight, kidney function, and overall health. For individuals with impaired kidney function or newborns, clearance of amoxicillin may take longer, potentially several days
. In summary:
- Half-life: ~1 hour
- 60% eliminated in 6 to 8 hours
- Fully cleared in about 8 to 12 hours for most people
- Clearance may be prolonged in kidney impairment or newborns
It is important to complete the full prescribed course to ensure effective treatment and prevent antibiotic resistance
