The latest time to buy Powerball tickets varies depending on the state or jurisdiction but is generally between one to two hours before the drawing. Powerball drawings happen at 10:59 p.m. ET on Mondays, Wednesdays, and Saturdays. For example, in Eastern Time Zone states, the cutoff for ticket sales is usually around 9:45 p.m. to 10:00 p.m. ET. In Central Time Zone states, it's typically around 8:59 p.m. CT, while Mountain and Pacific Time Zones may have earlier deadlines, sometimes as early as 6:45 p.m. PT. Some states like Maine have a cutoff at 9:50 p.m. ET, and in Florida, the cutoff is 10:00 p.m. ET for Powerball on draw nights. It's important to check the specific rules for the state or retailer where the ticket is being purchased because times can vary.