In My Hero Academia , Deku (Izuku Midoriya) loses One For All during the final war arc against Tomura Shigaraki.
Key Battle Event
Deku faces Shigaraki, who gains the upper hand, prompting a desperate strategy in the vestige world. He transfers One For All's component quirks one by one to Shigaraki, allowing past users to enter his mind and defeat All For One from within. This act destroys the quirk through blood transference, leaving Deku with fading embers.
Aftermath
By chapter 430, the embers fully extinguish as Deku graduates, returning him to quirkless status while his friends become pro heroes. The power's purpose—to end All For One—is fulfilled, ending its cycle intentionally.