The glands of the endocrine system help the body maintain homeostasis by secreting hormones into the bloodstream that regulate various internal functions. These hormones control the stability of body fluid composition, such as the concentration of salts (electrolytes) like sodium, potassium, and calcium, ensuring the fluids around the cells remain constant. Even small changes in these concentrations trigger endocrine responses that restore normal levels through negative feedback mechanisms. Additionally, the endocrine system maintains homeostasis of plasma volume and nutrient concentrations, such as blood glucose. Hormones like insulin regulate blood glucose by promoting its uptake and storage after food intake and increasing glucose production during fasting, ensuring a steady supply for metabolism. The hypothalamus and pituitary gland play central roles by directing hormone release to coordinate these responses and maintain internal balance despite external changes. Overall, the endocrine glands integrate body activities through hormonal signaling to keep the internal environment stable and functional.