The main cast of Fantastic Beasts and Where to Find Them (2016) includes:
- Eddie Redmayne as Newt Scamander, a British magizoologist and author of the book Fantastic Beasts and Where to Find Them.
- Katherine Waterston as Tina Goldstein, a witch and former Auror working for MACUSA.
- Dan Fogler as Jacob Kowalski, a No-Maj (Muggle) and aspiring baker who becomes involved with the magical world.
- Alison Sudol as Queenie Goldstein, Tina's free-spirited younger sister and a skilled Legilimens.
- Ezra Miller as Credence Barebone, a secret Obscurial wizard and adopted son of Mary Lou Barebone.
- Samantha Morton as Mary Lou Barebone, leader of an anti-wizard group.
- Jon Voight as Henry Shaw Sr., a newspaper owner.
- Carmen Ejogo as Seraphina Picquery, President of MACUSA.
- Colin Farrell as Percival Graves, a high-ranking Auror who is later revealed to be Grindelwald in disguise.
- Ron Perlman as the voice of Gnarlak, a goblin gangster.
- Faith Wood-Blagrove as Modesty Barebone, Mary Lou's youngest adopted child.
- Ronan Raftery as Langdon Shaw, Henry Shaw Sr.'s younger son.
- Josh Cowdery as Henry Shaw Jr., a U.S. Senator and Henry Shaw Sr.'s elder son.
- Kevin Guthrie as Abernathy, MACUSA supervisor.
- Jenn Murray as Chastity Barebone, one of Mary Lou's adopted children.
- Gemma Chan as Madam Ya Zhou, the Chinese ambassador witch to MACUSA.
- Johnny Depp as Gellert Grindelwald, the dark wizard antagonist disguised as Graves
This ensemble cast brings to life the story set in 1926 New York, focusing on Newt Scamander's adventures with magical creatures and the emerging dark threats in the wizarding world