The main cast of the TV series Car 54, Where Are You? (1961–1963) includes:
- Joe E. Ross as Officer Gunther Toody
- Fred Gwynne as Officer Francis Muldoon
- Beatrice Pons as Lucille Toody
- Al Lewis as Officer Leo Schnauser
- Charlotte Rae as Sylvia Schnauser
- Paul Reed as Captain Martin Block
- Hank Garrett as Officer Ed Nicholson
- Bruce Kirby as Officer Kissel
- Jimmy Little as Sergeant Jim McBride
- Nipsey Russell as Officer Anderson
- Albert Henderson as Officer Dennis O'Hara
- Ruth Masters as Mrs. Muldoon (Francis's mother)
- Jim Gormley as Officer Nelson
- Joe Warren as Officer Steinmetz
- Frederick O'Neal as Officer Wallace
- Others in supporting roles
For the 1994 film adaptation Car 54, Where Are You? , the cast includes:
- David Johansen as Officer Gunther Toody
- John C. McGinley as Officer Francis Muldoon
- Fran Drescher as Velma Velour
- Nipsey Russell as Police Captain Dave
This sitcom focuses on the comedic adventures of two mismatched New York City police officers patrolling the fictional 53rd precinct in The Bronx.