You generally should not drink alcohol while taking Prozac (fluoxetine) because the combination can worsen side effects and your underlying condition. It is important to discuss your specific situation with your own prescriber before deciding to drink at all.
Why alcohol and Prozac do not mix
Alcohol is a depressant and can worsen depression and anxiety, which Prozac is prescribed to treat. Combining them can also blunt the benefit of the medication, making your mood symptoms harder to control.
Both Prozac and alcohol affect the brain and central nervous system, so together they can increase drowsiness, dizziness, impaired coordination, and judgment, which raises risks for accidents, blackouts, or unsafe behavior. Some sources also note higher risks of confusion, irregular heart rhythm, and even seizures when they are mixed.
Safety guidance
Medical and mental‑health sources consistently advise avoiding alcohol entirely while on Prozac because of these risks. If someone does drink despite this advice, even small amounts can have a stronger effect than expected, so “just a little” is not automatically safe.
Skipping doses of Prozac on days you plan to drink is not a solution, because Prozac stays in the body for weeks, and missing doses can destabilize mood or trigger withdrawal‑type symptoms. Any ongoing alcohol use, especially heavy or frequent drinking, should be reviewed with a doctor, as it may require adjusting treatment or getting help for alcohol use itself.