It is not recommended to take Tylenol and DayQuil together because both contain acetaminophen. Taking them together can lead to an overdose of acetaminophen, which may cause serious liver damage. The safe approach is to avoid using multiple products containing acetaminophen at the same time and to follow the dosing instructions on the medication labels carefully. Typically, there should be a gap of 4 to 6 hours between doses of acetaminophen- containing products if changing between them is necessary. Always check the labels to avoid exceeding the maximum daily dose of acetaminophen, which is generally 4000 mg for adults, and consult a healthcare professional if uncertain.