Amoxicillin can sometimes make people feel tired, although tiredness is not a common or typical side effect of this antibiotic. The fatigue some people experience may be due to the infection being treated rather than the medication itself. When bacteria are killed, they can release toxins that cause weakness, and the immune system's effort to fight the infection can also lead to fatigue. In rare cases, amoxicillin and some other antibiotics might directly cause tiredness or weakness. Managing this fatigue involves getting adequate rest, staying hydrated, eating balanced meals, avoiding substances like alcohol that cause drowsiness, and consulting a healthcare provider if tiredness persists or is severe. It is important to complete the full course of amoxicillin despite feeling tired because stopping early can cause infection relapse and antibiotic resistance.
