Antibiotics generally do not directly cause tiredness or fatigue. However, some people may feel tired while taking antibiotics due to a combination of factors such as the body's immune response to the infection being treated and the disruption of good bacteria in the gut caused by antibiotics. Fatigue is not a common side effect for most antibiotics, but certain types like vancomycin may cause tiredness in some cases. Additionally, feeling tired is often more related to the underlying infection than the antibiotic itself. If fatigue is severe or interfering with daily activities, consulting a healthcare provider is recommended. Maintaining hydration, rest, and a balanced diet can help manage tiredness while on antibiotics.